Data from Phase II Trial on Investigational Oral Asthma Medication Show Promise by Targeting Airway Muscles

Posted on: 28 February, 2019

In the latest issue of Science Translational Medicine, researchers from the U.K. demonstrated positive results in the treatment of asthma with a new oral medication

This investigational drug, fevipiprant, blocks the prostaglandin D2 receptor, which has been implicated in allergic asthma. In this study, researcher demonstrated with biopsies of the airway that use of the medication led to decreased inflammation (through reduced airway smooth muscle mass, decreased eosinophilia among other markers.)

More research needs to be done and likely the medication is years from getting F.D.A, approval. However, once approved, the medication may provide another tool for the allergist to help manage difficult-to-treat asthma.

For more information, please visit this link: stm.sciencemag.org/content/

Conditions Treated

Allergy Shots

Allergy immunotherapy, also called “allergy shots,” is prescribed to modify the immune system’s response to allergens with the goal of minimizing and/or preventing an allergen initiated inflammatory response.
Allergy Drops & Tablets

Allergy drops, and tablets are two forms of sublingual immunotherapy that are injection-free alternatives to allergy shots. Both contain environmental allergen such as pollen, dust mites, molds, cat, or dog.
Asthma

Asthma is a chronic inflammatory lung condition that usually starts in childhood but can occur at any age. Allergists are considered the experts in asthma and diagnose this condition by history, exam and breathing tests of the airways.
Allergy & Sinus

Allergic rhinitis is one of the most common chronic conditions in the US. Individuals with allergic rhinitis develop allergy antibodies (IgE) targeted against allergens including pollen, animal proteins, dust mites, mold, and insect droppings.
Food Allergy

Food allergy affects 5% of children and 4% of adults in the United States and is defined as an adverse health event that is immune mediated and occurs reproducibly. Individuals with IgE mediated food allergy develop allergy antibodies (IgE) targeted against food allergens.
Allergic Rashes

Atopic dermatitis is a chronic, relapsing inflammatory skin disorder that usually starts at age < 5 years. It is characterized by itchy skin that becomes inflamed with scratching. For this reason, atopic dermatitis is known as the “itch that rashes.”
Other Conditions